魏海雷

工作经历

2017.09-至今 中国农业科学院农业资源与农业区划研究所，研究员，博士生导师

2017.09-2022.12     Cornell University（康奈尔大学），Visiting Professor

2013.01-2017.09  Cornell University（康奈尔大学），Research Associate

2010.01-2012.12  Cornell University（康奈尔大学），Postdoctoral Associate

2006.12-2009.12  中国科学院微生物研究所，助理研究员

2004.07-2006.11  中国科学院微生物研究所，研究实习员

学术兼职

中国农业科学院农业微生物资源创新团队，首席科学家

国家菌种资源库，常务副主任

中国农业微生物菌种保藏管理中心，主任

农业农村部农业微生物资源收集保藏重点实验室，主任

农业农村部肥料登记评审委员会，委员

山西省“百人计划”

中国农业科学院“青年英才A类”

BMC Plant Biology, associate editor

Frontiers in Microbiology, associate editor    

教育经历

2006.09-2009.06  中国科学院昆明植物研究所，植物学，博士

2001.09-2004.06  中国农业大学植物病理学系，植物病理学，硕士

1997.09-2001.06  山东农业大学植物保护学院，植物保护学，学士

研究方向

微生物资源与功能基因组

微生物-宿主分子互作

主持参与科研项目

华北麦玉两熟区生物障碍消减关键技术研发-国家重点研发计划

土传病害成因、流行规律与治理方案研究-国家重点研发计划

国家微生物资源共享服务平台运行补助项目-科技部科技基础条件平台项目

丁香假单胞菌III型分泌系统组分HrpH的多功能解析-国家自然科学基金

基于丁香假单胞效应蛋白多聚突变体D36E与Tn7-GATEWAY克隆技术的效应蛋白组学研究--国家自然科学基金

生防假单胞杆菌Ⅲ型分泌系统组成基因的克隆与超微结构鉴定—国家自然科学基金

基于微生物组学的新型植物防病促生制剂开发与应用-北京市科技计划

农业种质资源保护和利用-中国工程院战略研究与咨询项目

烟草青枯病与黑胫病并发规律与绿色防控研究-贵州省烟草公司遵义市公司重点研发项目

烟草青枯病精准预警关键技术研发-中国烟草总公司山东省公司重点项目

云南烟草黑胫病发生及微生态控制研究--中国烟草总公司云南省公司科技计划重点项目

学术论文（*通讯作者）

1. Zhang X^†, Ma YN^†, Wang X, Liao K, He S, Zhao X, Guo H, Zhao D, Wei HL*. Dynamics of rice microbiomes reveal core vertically transmitted seed endophytes.  Microbiome.  2022, DOI : 10.1186/s40168-022-01422-9

2. Luo Y, Wang J, Gu YL, Zhang LQ, Wei HL*. Duplicated flagellins in Pseudomonas divergently contribute to motility and plant immune elicitation. MicrobiologySpectrum ，2022, DOI : 10.1128/spectrum.03621-22

3. 王星, 何山文, 侯嘉玮, 魏海雷*, 张晓霞. 植物种子内生细菌组的研究进展. 微生物学报, 2022.

4. 马荣, 马毅楠, 王星, 谷医林, 魏海雷*, 张晓霞. 北京地区番茄青枯病健康和发病植株根际细菌群落比较分析. 中国生物防治学报, 2022,38(4):920-928.

5. Cong S, Li JZ, Xiong ZZ, Wei HL*. Diverse interactions of five core type III effectors from Ralstonia solanacearum with plants.  Journal of Genetics and Genomics . 2022 doi: 10.1016/j.jgg.2022.04.018

6. Zhang YN, Wang ZJ, Swingle B, Niu BY, Xu J, Ma X, Wei HL, Gao M. First Report of Rhizopus arrhizus (syn. R. oryzae) Causing Garlic Bulb Soft Rot in Hebei Province, China.  Plant Disease . 2022 Jul 20(ja).

7. Wang J, Luo Y, Gu Y, Wei HL*. Characterization of the SPI-1 Type III Secretion System in  Pseudomonas fluorescens 2P24.  Frontiers in Microbiology, 2021, 12:749037. doi: 10.3389/fmicb.2021.749037 (5.64)

8. 王若娜，马毅楠，李俊州，王远宏*，魏海雷*. 丁香假单胞菌Ⅲ型分泌系统组分HrpH酶学功能解析.  植物病理学报 , 2021, DOI: 10.13926/j.cnki.apps.000745

9. Gu Y, Ma YN, Wang J, Xia Z*, Wei HL*. Genomic insights into a plant growth-promoting  Pseudomonas koreensis strain with cyclic lipopeptide-mediated antifungal activity.  MicrobiologyOpen , 2020, 9(9), e1092, DOI: 10.1002/mbo3.1092 (3.139)

10. Xu N, Luo X, Wu W, Xing Y, Liang Y, Liu Y, Zou H, Wei HL, Liu J. A Plant Lectin Receptor-like Kinase Phosphorylates the Bacterial Effector AvrPtoB to Dampen Its Virulence in Arabidopsis.  Molecular Plant , 2020,13(10):1499-1512. doi: 10.1016/j.molp.2020.09.016 (13.164)

11. Gu Y, Wang J, Xia Z, Wei HL*. Characterization of a versatile plant growth-promoting rhizobacterium  Pseudomonas mediterranea strain S58.  Microorganisms, 2020, 8(3), 334; doi: 10.3390/microorganisms8030334 (4.123)

12. Sun BD, Chen AJ, Houbraken J, Frisvad JC, Wu WP, Wei HL, Zhou YG, Jiang XZ, Samson RA. New section and species in Talaromyces.  MycoKeys , 2020, 68:75-113. doi: 10.3897/mycokeys.68.52092 (2.984)

13. Guo HB, He SW, Wang X, Thin KK, Wei HL*, Zhang XX*. Bacillus telluris sp. nov. Isolated from Greenhouse Soil in Beijing, China.  Microorganisms , 2020, 8(5):702. doi: 10.3390/microorganisms8050702 (4.123)

14. 廖开吉，罗媛，夏振远，魏海雷*，曾凯芳*. 具有III型分泌系统的摩拉维亚假单胞菌FP1761植物益生功能及其全基因组分析.  植物病理学报 , 2020, DOI: 10.13926/j.cnki.apps.000341

15. 夏振远，谷医林，张宏越，魏海雷*. 复合微生物制剂改善土壤生物学特性和防治烟草黑胫病的研究.  中国土壤与肥料 , 2020, https://kns.cnki.net/kcms/detail/11.5498.S.20200929.1521.002.html

16. Bao Z, Wei HL, Ma X, Swingle B.  Pseudomonas syringae AlgU downregulates flagellin gene expression, helping evade plant immunity.  Journal of Bacteriology, 2020, 202(4): e00418-19. (3.49)

17. Xia Z, Lei L, Zhang HY, Wei HL*. Characterization of the ModABC molybdate transport system of  Pseudomonas putida in nicotine degradation.  Frontiers in Microbiology , 2018, 9:3030. doi: 10.3389/fmicb.2018.03030 (5.64)

18. Zhang W, Collmer A, Wei HL*. A  fliC flagellin mutant of  Pseudomonas syringae effectorless polymutant DC3000D36E reveals novel death elicitation activity in  Nicotiana benthamiana .  Phytopathology , 2018, 108 (10): 38-39. (4.025)

19. Wei HL*, Zhang W, Collmer A*. Modular approach to the type III effector repertoire in  Pseudomonas syringae pv.  tomato  DC3000 reveals a matrix of effector interplay in pathogenesis.  Cell Reports , 2018, 23(6): 1630-1638. (9.423)

20. Wei HL and Collmer A. Defining essential processes in plant pathogenesis with  Pseudomonas syringae pv.  tomato DC3000 disarmed polymutants and a subset of key type III effectors.  Molecular Plant Pathology , 2018, 19(7): 1779-1794. (5.663)

21. Hatsugai N, Igarashi D, Mase K, Lu Y, Tsuda Y, Chakravarthy S, Wei HL, Foley JW, Collmer A, GlazebrookJ, Katagiri F. Plant effector-triggered immunity signaling sector is inhibited by pattern-triggered immunity.  The EMBO Journal , 2017, 36: 2758-2769. (11.598)

22. Wang J, Wei HL^*, Chang RK, Liu HQ, Wang YH. First report of Strawberry bacterial angular leaf spot caused by  Xanthomonas fragariae in Tianjin, China.  Plant Disease , 2017, 101(11): 1949 (4.438)

23. Liu P, Zhang W, Zhang LQ, Liu XZ, Wei HL^*. Supramolecular structure and functional analysis of the type III protein secretion system in  Pseudomonas fluorescens 2P24.  Frontiers in Plant Science , 2016, 6:1190. doi: 10.3389/fpls.2015.01190 (5.753)

24. Lei L, Xia Z, Liu XZ, Wei HL^*. Occurrence and variability of tobacco rhizosphere and phyllosphere bacterial ccommunities associated with nicotine biodegradation.  Annals of Microbiology , 2016, 65: 163-173. (2.112)

25. Wei HL, Chakravarthy S, Mathieu J, Helmann T, Stodghill P, Swingle B, Martin G, Collmer A.  Pseudomonas syringae pv.  tomato DC3000 type III secretion effector polymutants reveal an interplay between HopAD1 and AvrPtoB.  Cell Host & Microbe , 2015, 17(6): 752-762. (21.023)

26. Xia Z, Zhang W, Lei L, Liu X, Wei HL*. Genome-wide investigation of the genes involved in nicotine metabolism in  Pseudomonas putida J5 by Tn5 transposon mutagenesis.  Applied Microbiology and Biotechnology , 2015, 99(15): 6503-6514. (4.813)

27. Lam HN, Chakravarthy S, Wei HL, BuiNguyen H, Stodghill PV, Collmer A, Swingle BM, Cartinhour SW. Global analysis of the HrpL regulon in the plant pathogen  Pseudomonas syringae pv.  tomato DC3000 reveals new regulon members with diverse functions. PLoS One , 2014, 9(8), e106115 (3.24)

28. Bao Z, Stodghill PV, Myers CR, Lam H, Wei HL, Chakravarthy S, Kvitko BH, Collmer A, Cartinhour SW, Schweitzer P, Swingle B. 2014. Genomic plasticity enables phenotypic variation of  Pseudomonas syringae  pv.  tomato DC3000.  PLoS One , 9(2), e86628 (3.24)

29. Wei HL, Chakravarthy S, Worley J, Collmer A. Consequences of flagellin export through the type III secretion system of  Pseudomonas syringae reveal a major difference in the innate immune systems of mammals and the model plant  Nicotiana benthamiana .  Cellular Microbiology , 2013, 15: 601-618. (3.715)

30. Wei HL and Collmer A. Multiple lessons from the multiple functions of a regulator of type III secretion system assembly in the plant pathogen  Pseudomonas syringae .  Molecular Microbiology , 2012, 85: 195-200. (3.501)

31. Wu S, Lu D, Kabbage M, Wei HL, Swingle B, Records AR, Dickman M, He P, Shan L. Bacterial effector HopF2 suppresses arabidopsis innate immunity at the plasma membrane.  Molecular Plant-Microbe Interactions , 2011, 24:585-593 (4.171)

32. Wei HL, Lei LP, Xia ZY, Liu PG, Liu XZ. PanB is involved in nicotine metabolism in  Pseudomonas putida .  International Biodeterioration and Biodegradation , 2009, 63: 988-992. (4.32)

33. Lei LP, Zhang W, Wei HL, Xia ZY, Liu XZ. Characterization of a novel nicotine-degrading  Ensifer  sp. strain N7 isolated from tobacco rhizosphere.  Annals of Microbiology , 2009, 59: 247-252. (2.112)

34. Yan Q, Wu XG, Wei HL, Wang HM, Zhang LQ. Differential control of the PcoI/PcoR quorum-sensing system in  Pseudomonas fluorescens 2P24 by sigma factor RpoS and the GacS/GacA two-component regulatory system.  Microbiological research , 2009, 164:18-26. (5.415)

35. Wei HL, Lei LP, Xia ZY, Liu S, Liu PG, Liu XZ. 2008. Characterization of a novel aerobic nicotine-biodegrading strain of  Pseudomonas putida .  Annals of Microbiology , 58:41-45. (2.112)

36. Zhang W, Wei HL, Gao HW, Huang GH. Cloning and Characterization of  ectABC  Cluster from  Bacillus alcalophilus DTY1.  Chinese Journal of Biotechnology , 2008, 24:395-400.

37. Wei HL, Zhang LQ. Quorum sensing influence root colonization and biological control ability in  Pseudomonas fluorescens 2P24.  Antonie van Leeuwenhoek , 2006, 86:267-280. (2.271)

38. Zhou HY, Wei HL, Liu XL, Wang Y, Zhang LQ, Tang WH. Improving biocontrol activity of  Pseudomonas fluorescens through chromosomal integration of 2,4-diacetylphloroglucinol biosynthesis genes.  Chinese Science Bulletin , 2005, 50:775-781. (11.78)

39. 雷丽萍, 夏振远, 王玥, 魏海雷, 刘杏忠.尼古丁降解菌株L1的分离与降解特性.  农业生物技术学报 . 2007, 4:721-722.

40. 魏海雷, 张力群.荧光假单胞杆菌2P24中 gacS 基因的克隆和功能分析.  微生物学报 , 2005, 45(3):368-372.

41. 张薇, 魏海雷, 高洪文, 胡跃高.土壤微生物多样性及其环境影响因子研究进展.  生态学杂志 , 2005, 24:48-52.

42. 张薇, 魏海雷, 张力群, 胡跃高.苜蓿菌核病生防菌及化学药剂的筛选.  草地学报 , 2005, 13:162-165.

43. 张薇, 魏海雷, 张力群, 胡跃高, 储国良.紫花苜蓿菌核病原鉴定及其主要生物学特征.  草业学报 , 2005, 14:69-75.

44. 魏海雷, 王烨, 张力群, 唐文华.生防菌株2P24与CPF-10的鉴定及其生防相关性状的初步分析.  植物病理学报 , 2004, 34:80-85.

45. 魏海雷, 周洪友, 张力群, 王烨, 唐文华.抗生素2,4-二乙酰基间苯三酚作为荧光假单胞菌2P24菌株生防功能因子的实证分析.  微生物学报 , 2004, 44:663-666.

国家发明专利：

1. 一株皱纹假单胞菌及其应用—魏海雷，谷医林，张宏越（专利号：ZL201910911436.9，申请日：2019.09.25，授权公告日：2020.02.14）

2. 一种植物免疫诱抗菌剂及其应用—魏海雷，谷医林，张宏越（专利号：ZL202010009448.5，申请日：2019.09.25，授权公告日：2021.06.18）

3. 青枯病防病促生菌剂及其应用—魏海雷，谷医林，张宏越（专利号：ZL202010009707.4，申请日：2019.09.25，授权公告日：2021.06.22）

4. 一株防病促生长托拉斯假单胞菌及其应用—谷医林，马毅楠，王为荣，魏海雷（申请号：202111192092.4，申请日：2021.10.13）

5. 一株有益根际假单胞菌及其应用—谷医林，张玉芹，马毅楠，王为荣，魏海雷（申请号：2021114308382.0，申请日：2021.11.29）

6. 番茄基因SlPKG及其编码蛋白在抗病中的应用—魏海雷，李俊州，从珅，马毅楠，谷医林，金雅（申请号：202211162978.9，申请日：2022.09.23）

7. 一种基于核心基因设计的茄科雷尔氏菌检测引物及其应用—魏海雷，马毅楠，从珅，廖开吉，谷医林，李俊州（申请号：202211417284.5，申请日：2022.11.14）

制剂与产品：

中华人民共和国肥料登记证：微生物肥（2022）准字（10873）号

联系方式

单位：中国农业科学院农业资源与农业区划研究所

地址：北京市海淀区中关村南大街12号资源楼204A

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