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魏海雷

发布者:管理员发布时间:2018-11-30作者:来源:点击量:

  教育经历:

  1997/09-2001/06  山东农业大学植物保护学院,植物保护,农学学士

  2001/09-2004/06  中国农业大学植物病理学系,植物病理,农学硕士

  2006/09-2009/06  中国科学院昆明植物研究所,植物与微生物学,理学博士

  工作经历:

  2004/07-2009/12  助理研究员, 中国科学院微生物研究所

  2010/01-2012/12  康奈尔大学(Cornell University), 博士后

  2013/01-2017/09  康奈尔大学(Cornell University), 副研究员

  2017.09-至今    中国农业科学院农业资源与农业区划研究所,研究员

  研究方向:

  微生物功能基因组学,主要内容包括:1)植物相关微生物III型分泌系统及其与宿主的分子互作;2)微生物资源的收集、功能与作用机制研究。

  专家类别:

  中国农业科学院“青年英才”

  社会任职:

  Frontiers in Plant Science,Frontiers in Microbiology副主编

  承担科研项目情况:

  丁香假单胞菌III型分泌系统组分HrpH的多功能解析-国家自然科学基金 (31871924)

  基于丁香假单胞效应蛋白多聚突变体D36E与Tn7-GATEWAY克隆技术的效应蛋白组学研究—国家自然科学基金 (31741106)

  中国农业科学院创新工程“青年英才计划”项目

  云南烟草黑胫病发生及微生态控制研究--中国烟草总公司云南省公司科技计划重点项目(2017YN08)

  生防假单胞杆菌Ⅲ型分泌系统组成基因的克隆与超微结构鉴定—国家自然科学基金(30700538)

  Population diversity of culturable endophytic nicotine-degrading bacteria in tobacco (Nicotiana tabacum L.)--国际科学基金(F/4583-1)

  “农作物重大病害多功能广谱生防菌剂研究和创制”子课题--”食线虫微生物的功能基因分子改造与菌剂制造”--国家“863”计划重大项目子课题(2006AA10A211)

  代表论著:

  Wei HL*, Zhang W, Collmer A*. Modular approach to the type III effector repertoire in Pseudomonas syringae pv. tomato DC3000 reveals a matrix of effector interplay in pathogenesis. Cell Reports, 2018, 23(6): 1630-1638 (*通讯作者) (IF="8.282)

  Wei HL and Collmer A. Defining essential processes in plant pathogenesis with Pseudomonas syringae pv. tomato DC3000 disarmed polymutants and a subset of key type III effectors. Molecular Plant Pathology, 2018, 19(7): 1779-1794.(IF="4.697)

  Hatsugai N, Igarashi D, Mase K, Lu Y, Tsuda Y, Chakravarthy S, Wei HL, Foley JW, Collmer A, GlazebrookJ, Katagiri F. Plant effector-triggered immunity signaling sector is inhibited by pattern-triggered immunity. The EMBO Journal, 2017, 36: 2758-2769(IF="10.557)

  Wang J, Wei HL*, Chang RK, Liu HQ, Wang YH. First report of Strawberry bacterial angular leaf spot caused by Xanthomonas fragariae in Tianjin, China. Plant Disease, 2017, 101(11): 1949 (*通讯作者)(IF="3.173)

  Liu P, Zhang W, Zhang LQ, Liu XZ, Wei HL*. Supramolecular structure and functional analysis of the type III protein secretion system in Pseudomonas fluorescens 2P24. Frontiers in Plant Science, 2016, 6:1190. doi: 10.3389/fpls.2015.01190 (*通讯作者)(IF="4.298)

  Lei L, Xia Z, Liu XZ, Wei HL*. Occurrence and variability of tobacco rhizosphere and phyllosphere bacterial ccommunities associated with nicotine biodegradation. Annals of Microbiology, 2016, 65: 163-173. (*通讯作者)(IF="1.122)

  Wei HL, Chakravarthy S, Mathieu J, Helmann T, Stodghill P, Swingle B, Martin G, Collmer A. Pseudomonas syringae pv. tomato DC3000 type III secretion effector polymutants reveal an interplay between HopAD1 and AvrPtoB. Cell Host & Microbe, 2015, 17(6): 752-762.(IF="17.872)

  Xia Z, Zhang W, Lei L, Liu X, Wei HL*. Genome-wide investigation of the genes involved in nicotine metabolism in Pseudomonas putida J5 by Tn5 transposon mutagenesis. Applied Microbiology and Biotechnology, 2015, 99(15): 6503-6514. (*通讯作者)(IF="3.420)

  Lam HN, Chakravarthy S, Wei HL, BuiNguyen H, Stodghill PV, Collmer A, Swingle BM, Cartinhour SW. Global analysis of the HrpL regulon in the plant pathogen Pseudomonas syringae pv. tomato DC3000 reveals new regulon members with diverse functions. PLoS One, 2014, 9(8), e106115(IF="2.806)

  Bao Z, Stodghill PV, Myers CR, Lam H, Wei HL, Chakravarthy S, Kvitko BH, Collmer A, Cartinhour SW, Schweitzer P, Swingle B. 2014. Genomic plasticity enables phenotypic variation of Pseudomonas syringae pv. tomato DC3000. PLoS One, 9(2), e86628(IF="2.806)

  Wei HL, Chakravarthy S, Worley J, Collmer A. Consequences of flagellin export through the type III secretion system of Pseudomonas syringae reveal a major difference in the innate immune systems of mammals and the model plant Nicotiana benthamiana. Cellular Microbiology, 2013, 15: 601-618.(IF="4.554)

  Wei HL and Collmer A. Multiple lessons from the multiple functions of a regulator of type III secretion system assembly in the plant pathogen Pseudomonas syringae. Molecular Microbiology, 2012, 85: 195-200.(IF="3.898)

  Wu S, Lu D, Kabbage M, Wei HL, Swingle B, Records AR, Dickman M, He P, Shan L. Bacterial effector HopF2 suppresses arabidopsis innate immunity at the plasma membrane. Molecular Plant-Microbe Interactions, 2011, 24:585-593(IF="4.332)

  Wei HL, Lei LP, Xia ZY, Liu PG, Liu XZ. PanB is involved in nicotine metabolism in Pseudomonas putida. International Biodeterioration and Biodegradation, 2009, 63: 988-992.(IF="2.962)

  Lei LP, Zhang W, Wei HL, Xia ZY, Liu XZ. Characterization of a novel nicotine-degrading Ensifer sp. strain N7 isolated from tobacco rhizosphere. Annals of Microbiology, 2009, 59: 247-252. (IF="1.122)

  Yan Q, Wu XG, Wei HL, Wang HM, Zhang LQ. Differential control of the PcoI/PcoR quorum-sensing system in Pseudomonas fluorescens 2P24 by sigma factor RpoS and the GacS/GacA two-component regulatory system. Microbiological research, 2009, 164:18-26. (IF="3.037)

  Wei HL, Lei LP, Xia ZY, Liu S, Liu PG, Liu XZ. 2008. Characterization of a novel aerobic nicotine-biodegrading strain of Pseudomonas putida. Annals of Microbiology, 58:41-45. (IF="1.122)

  Zhang W, Wei HL, Gao HW, Huang GH. Cloning and Characterization of ectABC Cluster from Bacillus alcalophilus DTY1. Chinese Journal of Biotechnology, 2008, 24:395-400.

  Wei HL, Zhang LQ. Quorum sensing influence root colonization and biological control ability in Pseudomonas fluorescens 2P24. Antonie van Leeuwenhoek, 2006, 86:267-280.(IF="1.795)

  Zhou HY, Wei HL, Liu XL, Wang Y, Zhang LQ, Tang WH. Improving biocontrol activity of Pseudomonas fluorescens through chromosomal integration of 2,4-diacetylphloroglucinol biosynthesis genes. Chinese Science Bulletin, 2005, 50:775-781.(IF="1.649)

  雷丽萍, 夏振远, 王玥, 魏海雷, 刘杏忠.尼古丁降解菌株L1的分离与降解特性. 农业生物技术学报. 2007, 4:721-722.

  魏海雷, 张力群.荧光假单胞杆菌2P24中gacS基因的克隆和功能分析. 微生物学报, 2005, 45(3):368-372.

  张薇, 魏海雷, 高洪文, 胡跃高.土壤微生物多样性及其环境影响因子研究进展. 生态学杂志, 2005, 24:48-52.

  张薇, 魏海雷, 张力群, 胡跃高.苜蓿菌核病生防菌及化学药剂的筛选. 草地学报, 2005, 13:162-165.

  张薇, 魏海雷, 张力群, 胡跃高, 储国良.紫花苜蓿菌核病原鉴定及其主要生物学特征. 草业学报, 2005, 14:69-75.

  魏海雷, 王烨, 张力群, 唐文华.生防菌株2P24与CPF-10的鉴定及其生防相关性状的初步分析. 植物病理学报, 2004, 34:80-85.

  魏海雷, 周洪友, 张力群, 王烨, 唐文华.抗生素2,4-二乙酰基间苯三酚作为荧光假单胞菌2P24菌株生防功能因子的实证分析. 微生物学报, 2004, 44:663-666.


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